Background: “Effect of Moringa oleifera soup on selected bio physiological parameters among adult with hypercholesterolemia working in selected tertiary Care Hospital”. Hypercholesterolemia is also called as dyslipidaemia or hyperlipidaemia. In past 20 years it is found that the threat of death related to disorders of abnormal lipid metabolism is increased upto 30%. Moringa oleifera is found to be economically and therapeutically effective in reducing the burden of raising health issue.

Methodology: The Quantitative research approach with pre-experimental one group pre-test post- test research design was used. Sample and sampling technique: this study included 40 adults and technique was convenient sampling technique. Setting: The research setting was Pondicherry Institute of Medical Science, Puducherry. Tools: validated self-structured questionnaire. After pre-test assessment of biophysiological parameters participants were given Moringa oleifera soup. After 21 days of intervention post-test assessment were done.

Result: The result shows that the effect of intervention on selected biophysiological parameters showed significant difference. Mean pre-test and post-test values of serum total cholesterol were 221.6±23.7 SD, 203.6±24.6 SD respectively with p-value < 0.005 level which is highly statistically significant.

Conclusion: The study findings revealed that there was a significant effect of moringa oleifera soup in selected bio physiological parameters weight, BMI, serum total cholesterol.